Your Treatment. Reimagined.

Today, localized therapy options are limited in providing physicians and patients with a customizable and confident treatment. Most options come with substantial trade-offs, dictating your ability to treat effectively. The NanoKnife System reimagines localized therapy through its unique mechanism of action, improving precision1, expanding versatility2, and increasing preservation2,3 giving you the control to tailor treatments with confidence.4,5

To learn more about the NanoKnife System visit


The NanoKnife System gives a physician the ability to sculpt and control the ablation zone through a variety of electrode configurations.1 IRE effectively destroys the targeted tissue and gives you precise treatment margins resulting in confident treatment coverage for your procedure.4,5


The procedure spares vital structures by retaining the structural integrity of the targeted tissue.2,3 The delivery of non-thermal energy allows for the preservation of the extra-cellular matrix, facilitating post-ablation, histological and functional tissue regeneration.2,3


Multiple electrode configurations, coupled with a unique mechanism of action, allow the device to be used in all segments of an organ to optimize treatment delivery.2 Electrodes can be confidently placed near vital structures, maximizing your ability to personalize treatment to your patient’s anatomy.4,5


AngioDynamics is sponsoring two key FDA-approved studies, DIRECT and PRESERVE.

The DIRECT study, sponsored by AngioDynamics, Inc., is an FDA-approved clinical study that is evaluating the effectiveness of IRE technology for the treatment of stage III pancreatic cancer. To learn more about the study and participating doctors, visit

The PRESERVE study, initiated by AngioDynamics, Inc. in partnership with SUO-CTC, will evaluate the use of the NanoKnife System as a focal therapy option for prostate cancer patients. It will assess the safety and effectiveness of the device when used to ablate prostate tissue in intermediate-risk prostate cancer patients. To learn more about the study and participating doctors, visit


1 Blazevski A, Amin A, Scheltema MJ, Balakrishnan A, Haynes AM, Barreto D, Cusick T, Thompson J, Stricker PD. Focal ablation of apical prostate cancer lesions with irreversible electroporation (IRE). World J Urol. 2020 Jun 2. doi: 10.1007/s00345-020-03275-z. Epub ahead of print. PMID: 32488359.

2 Scheltema MJ, Chang JI, van den Bos W, Gielchinsky I, Nguyen TV, Reijke TM, Siriwardana AR, Böhm M, de la Rosette JJ, Stricker PD. Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments. Diagn Interv Radiol. 2018 Sep;24(5):268-275. doi: 10.5152/dir.2018.17374. PMID: 30211680; PMCID: PMC6135060.

3 Li W, Fan Q, Ji Z, Qiu X, Li Z. The effects of irreversible electroporation (IRE) on nerves. PLoS One. 2011 Apr 14;6(4):e18831. doi: 10.1371/journal.pone.0018831. PMID: 21533143; PMCID: PMC3077412.

4 Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver. (2010);4(SUPPL. 1):99–104. doi: 10.5009/gnl.2010.4.S1.S99

5 Guidance for Selection of NanoKnife Probe Array Configuration and Ablation parameters for the Treatment of Stage III Pancreatic Cancer

AngioDynamics, the AngioDynamics logo, NanoKnife, and the NanoKnife logo are trademarks and/or registered trademarks of AngioDynamics, Inc., an affiliate or a subsidiary. © 2021 AngioDynamics, Inc. GL/ON/WP/1053 Rev 01 07/21

NanoKnife tumor environment technology image

Patients Are The Focus

John’s Story

I had my career, my family, my wife, and my daughter…

John Neet, a Stage III pancreatic cancer patient, shares the story about his fight.